RAF Typhoon FGR4s have joined forces with France's air force in a joint strike against an underground arms cache in Syrian territory operated by the IS group, according to the British defence ministry.
The facility, located using intelligence, was thought to be storing arms and explosives, the announcement noted, and was situated in mountains just north of Palmyra in the heart of Syria.
"Our aircraft employed Paveway IV guided bombs to hit a number of entry passages providing entry to the facility... initial indications are that the objective was successfully hit," the ministry announced.
There was no evidence of any harm to civilians in the operation on Saturday evening and every plane involved returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
Daesh - referred to as the so-called Islamic State - established jihadist rule over parts of Iraq and Syria until 2019.
"This strike demonstrates our UK leadership, and commitment to stand shoulder to shoulder with our allies, to eradicate any re-emergence of the terrorist group and their dangerous and violent ideologies in the area," Britain's Defence Chief John Healey stated.
British military aircraft have carried out overwatch operations over Syria to "forestall any attempted comeback" of the group after its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I want to thank all the members of British forces involved in this strike for their skill and their valour," Healey said. "Including them were a great many British personnel deployed over the holidays. This operation, to take out terrorist threats who pose a risk to our way of life, highlights how UK forces are always on standby, throughout the year, ensuring Britain's security domestically and powerful internationally."
During December, the United States armed forces executed what it termed a "major assault" on Islamic State objectives in Syria, subsequent to an assault claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations reports Daesh still has an estimated 5,000 to 7,000 combatants in Iraq and Syria.